LGD-4033 Powder (Ligandrol) | 2 Grams

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LGD-4033 (Ligandrol) Powder — 2 Grams

LGD-4033, also designated ligandrol or VK5211, is a non-steroidal selective
androgen receptor modulator (SARM) originally developed by Ligand Pharmaceuticals as an investigational compound.
This listing is a research-grade reference compound supplied in powder form for
in vitro and laboratory investigation. Identity and purity are third-party verified and documented
by a downloadable Certificate of Analysis.

• 97.25% purity (HPLC)
• Third-party verified
• 2,050 mg net
• Public COA
• UV-resistant foil pouch

Research Context

LGD-4033 was developed by Ligand Pharmaceuticals as a non-steroidal SARM that binds the androgen receptor with
high affinity and tissue-selective activity, and was later licensed for clinical development as VK5211. A
published Phase I study in healthy young men characterized its safety and pharmacokinetic profile and also
reported dose-dependent suppression of total testosterone, sex hormone–binding globulin, and HDL
cholesterol.^[1] The compound was subsequently evaluated in a Phase II trial in patients
recovering from hip fracture.^[3] Its metabolic fate has been studied extensively in anti-doping
research to support detection methods.^[2]

This material is supplied strictly as a reference compound to support such laboratory investigation. It is
not a therapeutic product, dietary supplement, or sports supplement, and no clinical or
performance outcomes are claimed or implied for any individual.

Scientific References

1. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87–95.
2. Fragkaki AG, Sakellariou P, Kiousi P, et al. Human in vivo metabolism study of LGD-4033. Drug Test Anal. 2018;10(11–12):1635–1645.
3. Viking Therapeutics. Viking Therapeutics initiates Phase 2 trial of VK5211 in patients recovering from hip fracture [press release]. PR Newswire; November 2015.
4. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004–2010.
5. World Anti-Doping Agency. The Prohibited List, Section S1.2: Other Anabolic Agents. WADA.org.