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ACE-031 1 mg
ACE-031 (Ramatercept) is a soluble fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) linked to a human IgG1-Fc region.
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Vedi i risultati di laboratorio →ACE-031 (Ramatercept) is a soluble fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) linked to a human IgG1-Fc region. By acting as a decoy receptor ('ligand trap'), it sequesters multiple TGF-β superfamily ligands — myostatin, activin A/B, GDF-11, BMP-9, BMP-10 — preventing their binding to native ACVR2B.
Research applications include broad TGF-β superfamily pathway investigation, myostatin/activin pathway dissection, and ligand trap pharmacology.
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3D Molecular Structure
Drag to rotate · scroll to zoomACE-031 1mg1 vial | KIT (10 vials)
| Chemical Formula | C133H227N43O33 |
|---|---|
| Synonyms | UNII-U8DGS69FVC, Myostatin inhibitory peptide 7, U8DGS69FVC, CHEMBL3410227, Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-Leu-NH2, BDBM50071379, ACE-031 Myostatin inhibitory peptide 7 |
| Molar Mass | 2956.5 g/mol |
| CAS Number | 1621169-52-5 |
| PubChem CID | 118732224 |
| Total Compound Content | 1 mg per vial |
| Shelf Life | 24 months |
ACE-031 is a recombinant fusion protein consisting of the extracellular ligand-binding domain of ActRIIB fused to human IgG1-Fc. ActRIIB is the primary type II receptor for multiple TGF-β superfamily members. As a soluble decoy receptor, ACE-031 sequesters myostatin (GDF-8), activin A, activin B, GDF-11, and — critically — BMP-9 and BMP-10. In preclinical rodent and non-human primate models, systemic ACE-031 administration produces significant skeletal muscle mass increases and improvements in contractile function, attributable to broad-spectrum ActRIIB ligand neutralisation. Total serum FSH suppression in ACE-031-treated animals reflects near-maximal activin pathway inhibition and is a pharmacodynamic biomarker used in preclinical dose-response characterisation. The broad ActRIIB ligand trap profile also co-inhibits BMP-9 and BMP-10 — TGF-β superfamily members involved in endothelial cell signalling — making this a relevant consideration in study design when vascular biology endpoints are being monitored. Supplied as lyophilised preparation (1 mg/vial). Independently third-party HPLC-tested; COA available per batch.
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Why does ACE-031 differ from myostatin-selective inhibitors in research applications?
ACE-031 functions as a soluble ActRIIB ligand trap, binding multiple ActRIIB ligands including myostatin, activins, GDF-11, BMP-9, and BMP-10. This broad ligand-binding profile allows investigation of combined ActRIIB pathway suppression rather than isolated myostatin inhibition.
In contrast, myostatin-selective approaches target GDF-8 specifically, making ACE-031 a valuable tool for studying the integrated contribution of multiple ActRIIB ligands to signalling, tissue regulation, and pathway cross-talk.
How does ACE-031 differ from myostatin-specific antibodies?
ACE-031 acts upstream as a receptor-based ligand trap that sequesters multiple ActRIIB-binding growth factors, whereas myostatin-specific antibodies selectively neutralize GDF-8 alone. This distinction allows researchers to compare broad ActRIIB pathway inhibition with highly selective myostatin blockade and evaluate the biological consequences of each approach across different experimental systems.
What endpoints are commonly evaluated in ACE-031 research?
Common endpoints include skeletal muscle mass, muscle fibre morphology, muscle function measurements, ActRIIB pathway biomarkers, Smad2/3 signalling activity, bone-related signalling markers, and expression of genes regulated by myostatin and activin pathways. These endpoints help characterize the effects of broad ActRIIB ligand sequestration and distinguish pathway-specific from multi-ligand responses.
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